I had the ARC Ref 6 in my systems for almost a month, courtesy of my buddy who let me audition it on its own and against my XP22. The amps are X260.8 mono blocks.
The Ref 6 is an amazing preamp. It throws a big, holographic soundstage with images that are slightly larger than life (this is both a Pro and a Con). Great combo with Pass amps. Natural sound, really nice.
With the XP22 in place of Ref 6, I get a more realistic presentation with soundstage nearly as big as Ref 6 but with images that are more lifelike. Better bass speed and definition (Ref 6 is a bit sloppy and wooly in the bass). Mids are, believe or not, slightly clearer with the XP22 and the highs are a bit sweeter/more extended. Volume control on XP22 with the X260.8 is more granular than on the higher gain Ref 6. With ARC you get bigger jumps in volume with each click. The XP22 has blacker, quieter background than the Ref 6.
I spent a good amount of time evaluating the Ref and comparing it to my XP22 to reveal these differences. Both preamps are excellent. In the end, I thought I would miss the Ref 6 but I really don’t.
To conclude, if I was to make the move up the preamp ladder, the XP32 would be at the top of my list.