Yes. It happens in commercial designs ALL the time.
Would I do it? No. Dropping the impedance to approx 1.5 ohms or lower in the midbass - where most music energy is - invites current dumping from the amp and generally overtaxes the amp. Yes, watts today are cheap (and speaker manufacturers are counting on that fact) but regardless, the quality suffers due to poor damping (control) from the amp. Of course, it depends how you are designing the box - ported or closed box. Either way, quality suffers unless you have a truly heroic (and generally very expensive) amp.
Better to stick with the parallel hookup, even though your overall sensitivity remains the same as a single driver. The reason for going with two is a sharp reduction in overall distortion since for a given sound level, two woofers are working less hard than a single one.
Steve Rothermel
Engineer/Associate