I have. Their are certain recordings I have that I like to run the DSPs on and depending on how I am listening, I will use different functions.
If I am listening at low levels, I turn on loudness. If I am listening to 80's hair metal or other poorly recorded music that lacks bass (Metallica before black album, Motley Crue's early stuff like Shout at the Devil) I have a DSP that is a bass boost to correct for the absence.
My room is open on either side so I tend not to have a bump in bass at 120hz so I don't use that but that will change when I move I bet. Certain bad recordings (usually bootlegs) I will turn on the d'esser. I will admit I do not use and do not like vinyl mode.
The DSPs are very easily accessed via a web browser. You just put the IP address in and it takes you to the page. The IP address is easily retrieved via the setup menu. Takes like 10 seconds to get it.