Issues of practicality. How long are you speaker cables? Or do you want to run a long interconnect to the power amp? Or do you go for an optimal set-up and bring the extra $$ for extra long cables or interconnects?
The LG OLED sits on a low (Sanus) stand pushed back almost touching the front wall. The backs of the speakers are over 3' out from the front wall. The audio equipment stand is tight in a corner, behind to the right of the right speaker, because that's already a long run of speaker cable to the left speaker. BTW, it's all set up on the long wall orientation.
The flat-screen TV made the biggest difference. I've tried various sound-absorbing/deflecting baffles sitting in front of/over the screen, and can hear no difference at all in the soundstage vs. naked.