If you biamp then you can make a modest improvement but I don't think this warrents being your main consideration in up-grading your speakers.
possible upgrade to biwire speakers
I started back in the serious realm (if not actual high end) of audio a few months ago with a Music Hall a25.2 integrated, maverick SACD player, marantz ST 7001 tuner, audioquest king cobra interconnects and type 4 speaker cable, and PSB Alpha B1 monitor speakers on sand filled sanus stands. Am now considering a slight step up in the speakers, among which the options include several biwire models. My question is whether or not such an upgrade will be worthwhile without an upgrade to biwire speaker cable at the same time.
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