I worked on two office systems for about fifteen years. For me, the objective was for my headphone system achieve magic… that status when you listen to it, it is delightful. For the speaker system it was realistic, natural punchy, with great imaging.
From a quick review, my first thoughts are a good quality streamer as Qobuz can sound as good or better than CDs or vinyl. To get there a great quality streamer is required (I like Aurender). Also, really good power conditioning. I would concentrate on those first and then see where you are.
If that doesn’t bring a smile to your face each time. Then let’s talk some more. I have a couple of my systems shown under my UserID… but not my office. It is Totem Mites + subwoofer, Prima Luna Integrated, Schiit Gungnir DAC, Woo WA-6SE headamp. My office is smaller probably 9’ x 12’. My main headphone system is now in the library (shown) now that I have retired.