I did it. The difference is not huge, but definitely noticeable, better inner detail and smoother high end without limiting the bass. Surprisingly, it also seems a bit quieter, counterintuitive when you're adding a tube. The best thing is being able to roll the rectifier, which in Dan's amps can tailor the sound. I really like the 5U4GB over the stock 5AR4.
My unit started out as a PH 9.0X, so results might be a little if you have the base model.