Thanks everyone.
Maril555, my cable box doesn't have 5.1 outs, that's why I need the processing.
BigBucks5, I did. It says no ht pass through, though I've seen people comment that it does. I figured they were doing what Kr4 suggested, but I was concerned that this might not be the greatest solution. Instead of writing all this out (and getting fewer responses) I asked the more general question.
Kr4 and Grannyring, in my case, I'd be using the Rotel amp section for the center and rear channels, and passing along the fronts to the C45, and then to the MC352. Will the volume be altered substantially for the different channels in this setup? I hope to eventually use the C45 for all channels. Thanks again.
Grannyring, what are your thoughts on C45 vs C46? Personally I think the C2200 is a bit too laid back for me.