If we can agree that we see differences in art or beauty that are are a consequence of physical, mental, and perhaps emotional, we begin to see the complexity in which are audio preferences are shaped.
We generally arrange our music systems to fit our surroundings. The speakers won't care, the cables won't either, if you are only getting 30% of the performance from them. If we want more precision, like picking up on a fine cable or vibration control, we need to push further.
IMO we need to get our rooms right if we want to learn to listen critically, otherwise there are too many variables. We will find good sound, but only with a perfectly set room, with extreme attention to reflection points (if you want imaging), etc. will the fruits of your labors be rewarded.
I've learned to set up my systems, and it's always meant repositioning speakers (not dedicated space most of the years). I've really been able to appreciate the nuances of a Nordost cable, or a dedicated line. IME most box speakers want to be 4-5 feet from the rear wall and a few feet from the sides. Put your speakers on beach towels, make big moves with them, look and create a listening hall in your room, create symmetry, soften the space with rugs and some diffusion. Play with filling the corners with pillows and place blankets around. Start big and refine.
So many times we have huge speakers in a shoe box room, inches from the walls with little thought of your hall, your room, the greater speaker, gets strangled in the chaos of confusion and suppression of the sound.
I would suggest an approach that's brought me some fun...think of your next listening session as hosting a concert in your space. Position your gear to get the most out of it (this has to be part of the audiophile process IMO). It might take 5-10 'concerts' to do this, but once your found your best stage or hall, or atmosphere, and volume, where there is no strain in the amp or overhang in the bass, your critical job is done so enjoy (until you pop in a new interconnect lol).
From this 'fundamental' positioning (whether it's permanent if dedicated or whatever) you have a new base to experiment with tone from a new tube, or a new power cable, etc. Most important thing to me is to enjoy this experience, have fun, and learn to have those performers emotion and passion in your room. Like anything else in life it takes lots of work and energy. Good luck.