I previously owned the DNA225, and once auditioned the Marsh A400 in home next to it. My speakers are Magnepan 3.6/R, which are quite revealing, and I found these amps a bit too forward and bright in the upper mids/treble in my system. However, they both present very clean sound, and might do quite well with warmer and/or dynamic speakers. To me the DNA225 is slightly more refined in the mid and upper ranges. (Warning: Adequate break-in is critical with both these amps before full evaluation.) In terms of bass, the A400 seems tighter overall, while the DNA225 delivers a bit more bass energy even if it's less defined than in the A400. Finally, the DNA has only RCA inputs, if that matters to you.