I have a pair of Wilson Maxx's in a 12x14 foot room and they sound great. Design wise, they have extremely well controlled bass. I've had smaller speakers in the room that were not as well balanced. It's taken a bit of work, including some room treatment to get them optimised. However, the room treatment has been focused on dealing with reflections - the room has needed no bass trapping. Ceteris paribus would the system sound better in a bigger room - yes. But while the answer to the question posed by jpwarren58 is no, every speaker/room combination needs to be considered uniquely.
Lose weight or buy better fitting pants
We talk about fixing the room constantly but couldn't the size and shape of the speakers be the problem?
I realize it is not economically feasible for manufacturers, but this could possibly relate to dyi folks.
For example a long narrow room with low ceilings would have speakers proportionate to the dimensions of the room. Smaller tweeters, drivers, with an enclosure mimicking the room. You would design the speakers to fit the room, instead of fixing the room. Start with the room as a extra enclosure. Make sense?