I've always had a simple rule - change only one thing at a time and spend plenty of time evaluating the change. Beyond vibration control, I don't go for tweaks*. I've seen too many people destroy both their systems and their musical enjoyment going down that rabbit hole. *I don't mean things like a proper mains installation or quality cables.
It’s all a matter of degree
It may be stating the obvious, but each A’goner will have his own idea of how far he must go to satisfy his addiction. To one member, enjoyment can be obtained with just a setup and no tweaks. Another will add a few or several and be satisfied. Then there are those who must go on an all out quest for nirvana which may never be sated.
Which camp are you in?