Possibly. Kind of depends, but it's rare. My approach is to stick to inexpensive solutions, but here's what I do:
- Use fully shielded interconnects
- Use shielded power cable for analog parts. These can be pretty affordable
- Use iFi power supplies where they matter, on my DAC and streamer to minimize the generation of AC noise.
- Use a power conditioner that starts working down in the audible range. That includes those Furman with LiFT and SMP features and TrippLite Isobar.
- Try to keep my network devices (switches, routers, etc) away from my audio, both physically and the power supplies out of the same clean zone.