Is bi-wire worse in some applications?

Some speaker manufacturers, Silverline among them, actually discourage bi-wiring. Follow the manufacturer's recommendations IMO.

I haven't attempted to use bi-wires since I have owned Pass Labs amps, which do not have two terminals, but felt that the Castle Howards I was using a year or so back sounded notably better with single wire connections rather than bi-wire. You may not be imagining things...

For all the speakers I have ever owned / that were biwire capable---all sounded better with 2 sep. runs of the same cable---whatever that wire happened to be. The last 4 speakers I have owned, don't allow b'wire.