I think you'll like the Zenith Mk3. For me, it was a vast improvment over the Zen Mini. I found that Stillpoint Ultra Mini's worked better than Iso Acoustic Orea's under the Zenith. Far and away the largest improvement I heard came from adding an Uptone Audio EtherRegen with Supra Cat8 ethernet cables between the wall jack and the Mk3. I use a USBePerfect USB filter and an Underwood Silver USB cable between the Zenith and DAC. I too leave the Zenith on 24-7 but reboot every two weeks or so. Because of DSP, I use Roon. When I tried it, however, Sense worked very well.
Enjoy