If you are looking for the best sound with an Innuos product you wont get there with Roon. The Innuos Sense App - which is a free server / player like Roon is custom made for their hardware.
Sense sounds way better than Roon.
If you are committed to Roon as a Server use the Experimental Mode with Innuos, it is better than Roon.
And, I agree running the Roon Server/Core on a different machine is better- I bought a used Antipodes Core for that because it is engineered to be an audio server. Now I use the Core as a NAS, it integrated with the Sense app easily.
If you are thinking of using Roons DSP it won't run well on an Innuos product, not enough CPU power, you will need a server.