I've tried a myriad of combinations placing my subs most everywhere else, but the symmetrical option has always prevailed; things simply fall into place sonically. Having an array of direct radiating subs around you can certainly envelope one with bass in a literal sense, but even a pair of horn subs 'envelope' in a way quite differently. The proof in the eating of the pudding, as they say.My speakers are flat to 20 Hz and for many years I have preferred speakers that allowed one amp to run the entire range. This was in part due to the fact that our amps are full power to 2Hz- much lower than most tube amps, and as a result play bass better because there is no phase shift in the audio band to mess with impact.
But when I've encountered standing waves (as I often have doing audio shows) its made no difference that my speakers go that low or are easy to drive. So my existing speakers are part of my distributed bass array, since the woofers cross over at 500Hz. That sorts out the bass nicely. But as you point out, integration is key; to that end the side/rear subs have to cross over below 80Hz so as to not attract attention to themselves.