The increased detail, clarity, resolution and extension are remarkable, but so is the amount of listening fatigue.
1. The "audiophile virtues" listed before the "but" are often, IME, associated with the fatigue problem stated after. Hard to maximize detail and clarity and ease of listening, since detail and clarity are often associated with edgy highs, esp. at your price point.
2. Do your speakers have metal drivers?; if so, this a possible cause of fatigue.
3. When you move to replace your speakers (a priority, IM0, if the answer to 2 is yes), look at Fritzspeakers, Fritz does nice silk dome designs at a good price, which are easy on the ears.
4. From the pictures, it looks like you have a "hard" room. Softening things up with plants, wall hangings and furniture could help.
5. I'm not sure if it will help with the edge, but adding an augment like jPlay or Pure Music to iTunes will likely make a noticible improvement, for short $. I use PM, and have heard good things about jplay.
6. If you have tinnitus (not unlikely) do not sell your rig. There is not a good treatment, but having music on makes the symptoms less bothersome, since it masks the ringing. Get an spl meter, and keep it below 85.
Just my 3c. Good luck, and keep us posted.
John