I am a little puzzled by your opinion on second sub. Yes, it probably would require room correction by eg MiniDSP (between pre and subs), but presumably having two subs in “opposing” corners should help in smoothing out the general room response.
You don’t have opposing corners, really, you have complex modes that include all of the open space.
Or are you just concerned that room shape + mains + 2 subs would be too complex? It seems these days a bit of REW + Dirac shouldn’t be too hard to manage, but I am inexperienced.
I think if you do 1 sub right you’ll be exhausted and happy. Take a look here though if you want to see what’s involved in optimizing multiple subs:
https://www.minidsp.com/applications/subwoofer-tuning/tuning-multiple-subs
While I really like the app note I tune my subs to peak between 20Hz-30Hz and descend about 1.25 to 1.5 db/Octave until the crossover point. I find this much more musical than flat. JL Audio and Dirac seem to agree with me.
Last bit of advice: 1 sub, well integrated, is glorious. Most people get 1 sub and cant' do it well so go looking for more ways to fix their problems. I assure you, if you get 1 sub working well, EQ your two mains to match each other, you'll be in a really good place.
Best,
Erik