One thing about the influences musicians bring to the music they make is that, if a player and the band he is in (assuming he's not a solo artist) becomes very popular, he can actually change the course, the direction, that Popular music takes. When the more Blues-based bands of the mid-60's began their ascent, they did just that. Rock 'n' Roll music had become very devoid of much of a Blues influence by the time The Yardbirds and their ilk reintroduced it in 1964-5 and onward. It was putting hardcore Blues into Rock 'n' Roll that turned it into the Rock music we have known ever since.
Clapton was at the forefront of that change in the direction the music took, so it was really significant that when George Harrison played him The Band's Music From Big Pink in the middle of 1968, the rug was pulled out from under him. In The Last Waltz, Eric says: "Music had been moving in the wrong direction for a long time. When I heard Music From Big Pink I thought, someone has finally gotten it right" (I'm paraphrasing). He immediately disbanded Cream (the biggest band in the world!) and went to West Saugerties, NY to, he intended, join The Band. That of course didn't happen, but he did take their cue and started making a different kind of music.