My room is a bit of a challenge with it's smallish (11' x 17') size. I have the speakers a bit closer to the side walls than they should be, but that's to get them 8' apart for a bigger, broader soundstage. The subs are just to the inside of the speakers. REL recommends them to the outside, but say inside also works if there are space constraints. Despite the challenges it all sounds great....better than I would have thought otherwise.
My wife and I plan to move the whole thing to our living room, which is 13.5' x 22', and 1/2' taller (8.5' vs 8'). That should give it all more room to breath and allow positioning the subs to the outside of the speakers. We have some logistic things to work out first though (e.g. turntable isolation).