I've messed with "high end" cables since the late '80s. Yeah, you can hear a difference. Maybe you shouldn't- that is, the cable is coloring the sound. I dunno.
One serious guy I know swears by basic old stock Rat Shack and his system is beyond the pale.
I think the one advantage of a "full loom" is that it enables you to hear the "house sound" of that brand/line. Cabling can be tricky if you are trying to use it to compensate. I use very basic stuff in my vintage system- trying to stay close to period. In my main system, I had great success with Kubala-Sosna, which nicely matches the character of my system. But, I can't extrapolate. I will say K-S stepped up when a very long XLR had a bad connector- 17 years later. He replaced it at no cost and no cost shipping back.
If you do indulge in cable comparisons, you can get a headache. There are some known synergies for people with certain speaker/amp combos. I would start there if that's a question.
I'd also say, with some experience, that I would rank the importance of cabling low on the priority list if you are building an entire system from scratch. The cables can make a difference but I wouldn't put cart before horse (or something).