Ones ears are a far more sensitive instrument than all of the commonly used measurements / charts taken together by an enormous amount. Trained ears / mind is an order of magnitude more sensitive.
So 100% ears.
There may be some top high end audio designers that are able to tell what something will sound like with many measurements of various variables.. after decades of experience. But for those that want to assemble a system, learning about sound and training your ears by listening is the only reasonable approach.