For me swapping in a quality Dac into my Audio Research pre and power amp rig was my first step to going pre-ampless. Next my friend talked me into selling him my ARC SP 15. Now I am DAC connected by XLRs to my ARC power amp and loving it. To me the sound is "cleaner" - specifically the bass which is more controlled and faster. The mids sound the same and the tweeters are sharper. I suppose that is all due to the voicing ARC built into the SP 15.
Looking back my conclusions are thus: 1) A pre gives you more volume. 2) A pre colors the sound which may or may not be a bad thing depending on what you prefer. I have a few years more experimenting to go before I have a solid table pounding resolution to this question. For now I like DAC direct to tube amp.