@hifidream thanks for that link. I have a pretty good idea now of the various set up configurations that can be supported. It appears though that the RME interface is a critical piece of the puzzle. Perhaps I am missing something, but it appears I would not be able to use my current preamp in the chain (unless it can be inserted in front of the RME). That is probably a deal breaker for me in my 2-channel system, probably not so much for a headphone set up I am thinking about setting up.