Chris - I tried bi-wiring my center channel with it which was a very short run, about 5 feet but I used 2 cables and then splitting up the conductors. The mains are single runs and it did an adequate job @ 8' each. IMHO, I think its too small a gauge to bi-wire with for any long distance, say 8' or more if you were to use just a single cable per side. If you are hell bent on bi-wiring then run 2 cables per side because 1. the distance warrants it and 2. since you are running 100 watts into a 4 ohm speaker. If you are not one to believe that bi-wiring provides benefits and while I think the AQ 4+ is a good entry level cable you could be better served by purchasing a higher quality cable in single wire version. Buying used here might net you a better bang for the buck then buying brand new AQ4+ - if thats what your intention is.