I just built two double-run ("shotgun") PCs out of LoRad 2.5 with Furutech Edison and IEC connectors (FI-25M-N1, FI-25). The shotgun construction gave me the equivalent of 9 AWG wire. I'm using them for a Cambridge Audio Azur 840C CD player and a Perreaux SM6 MKII preamp. The PCs now have about 25 hours on them.
The improvement over stock PCs was apparent immediately, and the improvement was dramatic. The improvement was on all dimensions -- spatialization, dynamics, timbre and definition.
I completed the work on the PCs at about 2:30am one morning, started listening immediately, and was so pleased with the result that I stayed up listening to various tracks for another hour. I should have taken some time to burn in the cables, but I was impatient.
I was most impressed with the difference in the clarity in renditions of complex orchestral music -- e.g., Solti's Chicago Symphony performance of Beethoven's Ninth Symphony. Before installing these cables I had a slight "muddle in the middle" ranges of complex passages with rapid transients -- this despite numerous upgrades in ICs and mods to my vintage Polk Audio SRSs. These prior improvements had significantly reduced the "muddle," but did not completely eliminate it. Installation of the Supra LoRad 2.5 PCs appears to have eliminated it.
I can't say how single runs would work, but this particular shotgun build with LoRad 2.5 produced a great result for me, far better than I expected. I also found the cable much easier to work with than other 9-12 AWG cable.