Here is my view regardless of hybrid or all tube.
single gain stage: Pure, more open sound. Less dynamic, roll off top and bottom end.
multiple gain stage: wider bandwidth, dynamic. More complex.
A good design of multiple gain stage can improve on noise level and transparency. It can also sound very open.
However, it is hard to do it right.
As far as hybrid vs all tube goes, the Power supply section do influence sound but either way is fine.
Mixed gain stages can be tricky. It can be quiet and dynamic at same time. However, poor mix can sound thin.
single gain stage: Pure, more open sound. Less dynamic, roll off top and bottom end.
multiple gain stage: wider bandwidth, dynamic. More complex.
A good design of multiple gain stage can improve on noise level and transparency. It can also sound very open.
However, it is hard to do it right.
As far as hybrid vs all tube goes, the Power supply section do influence sound but either way is fine.
Mixed gain stages can be tricky. It can be quiet and dynamic at same time. However, poor mix can sound thin.