I don't know that I have ever appreciated a change in the midrange of my system with the subs active. It is very intriguing how this could even happen with nothing changing at the signal the main speakers are receiving.
The best answer to this is that removing bass from a mid-woofer reduces doppler distortion, which makes it's way up into the midrange.
I'll wager dollars to doughnuts that six nines have never heard a properly integrated sub.
Most people really have not.