I have not heard the mk VI, but have the mk IV and I've tried a couple of things.
On my amp/system, fuses had a very marginal impact.
Rolling 12ax and 12at tubes had a significant impact.
Replacing stock kt88 for shuagang treasures had a very significant impact. Maybe even more than with the smaller tubes, but frankly a lot of time went by between one and the other roll.
Including a Bybee on the line-in had a significant impact.
On my amp/system, fuses had a very marginal impact.
Rolling 12ax and 12at tubes had a significant impact.
Replacing stock kt88 for shuagang treasures had a very significant impact. Maybe even more than with the smaller tubes, but frankly a lot of time went by between one and the other roll.
Including a Bybee on the line-in had a significant impact.