Your opinions on how to string 25 ft speaker cables

I am running them through a hole in floor to crawl space, then up through floor to speakers. There are four cables to each speaker (Bi-wired)B&W 604s2 plus a subwoofer, Vandersteen 2WQ, (2 cables) nearby. Using 12 AWG two strand 99.9 copper nothing special cable from Monoprice. Should they be twisted around each other, or run separately and far apart, or in some other magical configuration for best of the best of the best, sound?