It's pretty much conventional wisdom that all cables need to get out of the way of the music, so why put more cable in the way of the music? My experience is not as vast as others here but I've had stranded and solid core, copper and silver, heavy and light gauge, and heavy duty terminations. and the best I've found is the thinnest, single strand of silver supported in an oversized tube with connectors pared down to the minimum to get the most out of my system, getting the most out of the way of the music.
All the best,
Nonoise