Because speaker sonics depends on speaker materials, design, and execution, the OP’s question is so general that’s it’s difficult to give specific advice beyond generalizations which offer very limited value.
What type of speaker would sound better?
1. mid-tier 3 way with multiple lower quality drivers and parts OR
2. High end 2-way with premium crossover parts and speaker drivers.
Either one could be a stand mount, small tower, or anything in between.
For example you listen to a well recorded symphony in a 15 X 30 living room. You have 250w @ 8ohms. You start on a mid tier 3-way and then on a high end 2-way system, which do you think would sound better?