I would say a high-end two way, especially if it has a decent sized woofer that can push a fair amount of air. I think, however, that you might want to add a few other variables. What kind of music do you listen to? How loud do you usually play it? If you want rock-down-the-house rock n' roll... ? I'd probably still go high end.
What type of speaker would sound better?
1. mid-tier 3 way with multiple lower quality drivers and parts OR
2. High end 2-way with premium crossover parts and speaker drivers.
Either one could be a stand mount, small tower, or anything in between.
For example you listen to a well recorded symphony in a 15 X 30 living room. You have 250w @ 8ohms. You start on a mid tier 3-way and then on a high end 2-way system, which do you think would sound better?