I’m going to be a bit of a contrarian...
As long as you stay within the same design family, and you’re not too obsessive about the various shades of goodness, and the speakers are generally well-known and discussed, I think it’s a pretty low-risk endeavor. Oh, and you don’t have unrealistic expectations based on a price point. That’s a biggie.
Given your current setup, would I purchase a set of Magnepans, or Martin Logans, or even a set of monitors without listening? Probably not. A set of 2 1/2 way or 3-way floor standers with a dome tweeter and cone mid-range / woofers? Sure.
If you purchase used, it’s even a lower-risk endeavor (from a monetary perspective). I highly doubt the OP is considering $100k speakers. Audio shows may be the best way to look at equipment, but it’s probably the worst way to listen to equipment.