"How "safe" do you want to be?
Personally, I'd never buy any speaker I couldn’t first audition in my room.
Your money.
Your ears. "
I'm pretty sure this rarely happens. Its a great idea, but I can't imagine many dealers are going to let you take expensive speakers home, unbox them, audition them,re-box them and then bring them back. They may sell them too you, and let you bring them back with a restocking fee.
I think if you read enough. You can pick a brand/model that works well with your existing gear. I always stay with well known brands that have good resale value.