If you must run long runs of interconnects and you have the option, balanced is better. Balanced interconnects are used in professional circles for just that reason. More gain, and less likely to act like antennas for the unwanted garbage floating around. Balanced connections are not a panacea,how ever. A well executed single ended system can easily out perform a poorly executed balanced one. It is much more expensive to build a truly balanced system than a single ended one. Some times the money may be better spent elsewhere. Good listening.