For me and my systems, "tweaks" are improvements such as Herbie's Loudpeaker Feet. These were recommended on the Double Impact thread and I ordered them with trepidation because they were about $65 a speaker and the design improvement was not clear at first.
Turns out they work splendidly with the Tektons and are well worth the minor investment -- the speakers stay rock steady over time and the subtle cushioning improves bass response, soundstage, and security.
Have had my share of non-working tweaks and can only say that I will spend relatively little on an untrusted, untested, or non-reviewed addition. Spend time on Audiogon and other sites to benefit from user comments on these kinds of threads. Believe you get the best information from users/owners who describe their experiences devoid of special interest or economic motives.
The cable issue stopped being a concern for me when I discovered Blue Jeans Cable 7 years ago and started using their custom builds for studio and home setups. Check out Gearslutz for studio advice on cables. The standard used to be Monster mic cables but these have been replaced by Belden 1800f ones. Blue Jeans makes custom lengths and connectors so you avoid excess length and adaptors.
Like bstbomber above, am a lifelong musician with studio and audiophile setups. Move equipment back and forth between the two and have found that professional studio equipment always sounds good in audiophile settings but the reverse is not always the case.