Reading the great posts triggered another memory. I had bought a store's (several years old) demo unit of a highly regarded PP 300B amp, with its tubes. Some months later, as I was listening, smoke came out of the ventilation grid on the chassis top, and a bright red anode appeared. A 300B tube filament had sagged and touched the grid. Instant destruction of the tube and the bias resistor.
I sent the amp back to the factory where they repaired the damage and installed the protection circuitry of the newer version. To this day I try to never leave a running tube amp unattended for any extended period.
The 300B specs do state that the tube is best used used in a vertical position, or if that is not possible, with the filaments' long sides vertical.