Probably depends on the manufacturer.
Many of my old Audioquest cables have arrows that indicate the recommended "direction" of the signal -- like if you're connecting a preamp to an amp, the interconnect should be oriented with the arrows pointing at the amp.
Likewise, for source components, the arrows should point away from the signal source and toward the preamp.
Supposedly, the interconnects had directionality that affected the sound, though I could never hear any difference.