I'd suspect the fatigue you are concerned about comes from those products which enhance detail while also inducing an overly bright presentation and/or adding a potential grain and hash along with the enhanced detail.
In addition, those products that round off the edges of initial attack and decay turning what should be a very crisp and clear and otherwise exhilerating dynamic passage into something more monotone/flat and boring are typically more fatiguing that those that do not.
Whatever the case, I'd recommend auditioning the Audience Au24 cable line-up to reduce fatigue in the true sense.
-IMO(of course)
In addition, those products that round off the edges of initial attack and decay turning what should be a very crisp and clear and otherwise exhilerating dynamic passage into something more monotone/flat and boring are typically more fatiguing that those that do not.
Whatever the case, I'd recommend auditioning the Audience Au24 cable line-up to reduce fatigue in the true sense.
-IMO(of course)