It works with some speakers, does not with the other. Same as what your speakers are connected to. So as it was already pointed out, tuning is the key.
In my case a pair Focal 948 on spikes (spikes are built into the base) do sound different, and I would argue cleaner, then without spikes. Same goes for Paradigm Esprit-BP (from the 90's); especially the lower tones, became more articulate and better pronounced. Same goes for Visaton La Belle that I built last year. Perhaps the change has to do with the height of the speaker (on the spikes is higher), but I kind of doubt it. With studio monitors JBL L90, adding spikes to the stands makes no difference whatsoever. So as I said, the key is in tuning. Goes without saying, your system has to be fine enough to make the difference obvious.