I always thought separates (power amp & pre) were the way to go and went through agony trying to get a good match, although integrateds always appealed to me as well if one could live with a passive linestage because the issue of matching pre and power amp would be gone. Also integrateds have the advantages of hard wiring over IC's. My current amp is an HK990 which has an active line stage and an adjustable gain feature which is intended match the outputs of various sources but which can be used to match pre and power amp without any apparent degradation in sound quality. It is an answer to one aspect of system synergy although I don't know of any other integrateds that feature this. The integrated would have to have an active line stage in order to achieve the adjustable gain.
Another major factor would be matching amp to speakers so that the amp would have enough damping ability to control the drivers but not so much that it overdamps causing a thin qquality with loss of bass. Paul Speltz addresses this issue with his autoformers. You can read research conducted on this issue on his website.
Another major factor would be matching amp to speakers so that the amp would have enough damping ability to control the drivers but not so much that it overdamps causing a thin qquality with loss of bass. Paul Speltz addresses this issue with his autoformers. You can read research conducted on this issue on his website.