System set up in front of corner Vs flat wall - acoustical issues?

The room size is about 22 x 16 and because of lay out I'm considering having a corner of room be the backdrop of the system.  It's a combo home theater/ two channel listening environment.

Each shorter side of the room has either a window or a French door exit, so it's difficult to put the system along the shorter walls which would be a lot better. Putting system in the middle of the longer wall presents a challenge for seating environment. Too much space on each side of this rectangle room.

I haven't seen any systems with main speakers set in front of a corner. It would seem to be a more comfortable layout but I wonder what the acoustical challenges might be.