I think so. Mating the speakers to the room is a huge consideration in speaker selection. Large speakers tend to have more bass output with lower extension. Those traits are more likely to excite the resonsances and modes of a smaller room. Small speakers are more forgiving of the room.
WIth that generalization said, there's more involved than just speaker size.....bass loading techniques (ported, sealed, TL, horn, etc) and cabinet design can vary a lot, and is certainly a factor.
WIth that generalization said, there's more involved than just speaker size.....bass loading techniques (ported, sealed, TL, horn, etc) and cabinet design can vary a lot, and is certainly a factor.