Only if you can't fit anything else in the room ;-)
Seriously, I've had wonderful experiences with large speakers in fairly small rooms. One of my fondest memories is of a homemade JBL professional series speaker system (circa 1971) with very large horns for the midrange and tweeter and 15-18 inch woofers all housed in large cabinets in a room no bigger than 12 by 15. The sound was great. Usually, it's the bass that might be too "large" sounding with large speakers in a small room, but video systems tend to have one or two subwoofers so a large speaker system in a small room may simply remove the need for one or both of those. My two cents.
Seriously, I've had wonderful experiences with large speakers in fairly small rooms. One of my fondest memories is of a homemade JBL professional series speaker system (circa 1971) with very large horns for the midrange and tweeter and 15-18 inch woofers all housed in large cabinets in a room no bigger than 12 by 15. The sound was great. Usually, it's the bass that might be too "large" sounding with large speakers in a small room, but video systems tend to have one or two subwoofers so a large speaker system in a small room may simply remove the need for one or both of those. My two cents.