I also use ISO Acoustics Gaia under my speakers, and there is no doubt that they improved the sound over spikes. They don't decouple fully, but work well in that direction, and, along with the likes of related Townshend products, reduce the "smear" that results from vibration, and also improve the focus of bass response.
The disadvantage, at least for some (not in my case), is that hard-coupling devices like spikes do transmit more bass energy to the floor, and some listeners prefer to have that visceral feedback, which is reduced with the use decoupling devices.