There is no perfect way. Put in a position where they sing to you. At that point you can add room treatments. If you feel you need a lot of room treatment you might have the wrong speakers or preamp or Amp.
Speaker Positioning
I know from speaker position is critical in achieving the best results from a given system. Is there a dynamic way to measure placement of each speaker to make certain they are the exact same distances from back/side wall, cabinets, seating, etc. beyond a measuring tape and listening to the results? Seems to me if minor differences pay large returns, you could be tinkering with this a long time. Thanks for the indulgence.