Short answer: I don't know.
However DIY enthusiasts on this forum experimented quite a bit with different materials in Helix builds and do use better quality (bare silver or Ohno Cu wire in teflon tube) for one and stranded Ohno Cu for the other. I've been experimenting with these and they are a real improvement, although I didn't try different alternatives within the design.
Bottom line: I would not discard it makes a difference until I hear them, despite not understanding why this is so (I'm an engineer BTW, so quite familiar with the basics of alternating current).