Yes, IMHO AES/EBU will provide the best quality up to 24/192 kHz and single rate DSD, for higher sampling rates you'll need USB or I2s.
I've never compared it to I2s but it's been better than USB in every comparison I've done.
SPDIF vs. AES/EBU Sound Quality?
All else being equal (same cable, etc.), will the AES/EBU connection provide better sound quality than SPDIF? I just realized by Lumin U1 mini has AES/EBU output and one of my DACs (my favorite) has AES/EBU input.
A forum search and even a google search pulled up nothing definitive and I figured I'd ask before buying an $$$ AES/EBU cable